Upper Respiratory Tract Uptake of Naphthalene

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Upper respiratory tract uptake of naphthalene.

Naphthalene is a nasal toxicant and carcinogen in the rat. Upper respiratory tract (URT) uptake of naphthalene was measured in the male and female F344 rat at exposure concentrations of 1, 4, 10, or 30 ppm at inspiratory flow rates of 150 or 300 ml/min. To assess the potential importance of nasal cytochrome P450 (CYP) metabolism, groups of rats were pretreated with the CYP inhibitor 5-phenyl-1-...

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ژورنال

عنوان ژورنال: Toxicological Sciences

سال: 2009

ISSN: 1096-6080,1096-0929

DOI: 10.1093/toxsci/kfp138